Select second last element with css

The CSS selector nth-of-type can be a number, an equation or odd/even. Is it possible to select nth from end instead of nth from the beginning?

I’m using a plugin to modify webpages I visit. There’s a varying number of menu items depending on circumstances, but the item I want to remove is always 2nd from the bottom.

I’m not sure where to begin, just wondering if it’s possible.

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